Description

According to officials, researchers at the Indian Institute of Technology (IIT) Jodhpur used state-of-the-art genome sequencing technologies to identify changes in the RNA of the COVID-19 virus. The researchers also looked into how these intra-host variations get fixed into extra-host variations, as well as mutations that lead to variants. The two-phase study's findings were published in the journal "Nucleic Acid Research."

"Within the host cells, the COVID-19 virus's RNA structure constantly undergoes small changes (intra-host variations). These changes take place at the nucleotide level, with nucleotide serving as the RNA molecule's building component. Many of these intra-host differences are induced by enzymes produced by the immune system in the host cell "IIT Jodhpur's Mitali Mukerji is the head of the department of bioscience and bioengineering.

"As a result, many of these variants are either innocuous or even harmful to the virus. Some changes, on the other hand, can improve the virus's survivability and become fixed as extra-host variations, which could lead to variants of concern "she continued.

Using an Illumina sequencing platform, the researchers looked at intra-host Single Nucleotide Variations (iSNV).

According to the topic, during the first phase of the project in 2020, they mapped the iSNV across the RNA structure of virus samples gathered from China, Germany, Malaysia, the United Kingdom, the United States, and various subpopulations of India.

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